IndraLab

Statements

Cis-doxepin binds KCNH2. 2 / 2
| 2
reach
"Whilst obligatory molecular determinants of doxepin binding to HERG remain to be found, the fact that I HERG inhibition by doxepin developed progressively over several minutes following rapid external solution exchange is consistent with the drug crossing the cell membrane to reach its site of action."
17560554
reach
"Neither the Y652A nor F656A mutations attenuated blockade by doxepin concentrations producing very high levels (> 90%) of blockade of WT I HERG, suggesting that neither residue is absolutely obligatory for doxepin binding to HERG channels to occur."
17560554