IndraLab

Statements



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"These results indicate that endogenous ATXN3L promotes breast cancer cell proliferation partially through stabilizing KLF5."

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"Since ATXN3L stabilizes KLF5 and inhibits the expression of p27 and p21, it is plausible that ATXN3L also promotes breast cancer cell proliferation."

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"Consistently, knockdown of ATXN3L by shRNAs significantly decreased cell proliferation in both breast cancer cell lines, as measured by CCK-8."

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"Our findings in this study suggest that ATXN3L promotes cell proliferation but not cell migration."

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"Functionally, knockdown of ATXN3L inhibits breast cancer cell proliferation partially through KLF5."

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"In summary, our study identified ATXN3L as a KLF5 DUB in breast cancer and found that ATXN3L stabilized the KLF5 protein and promoted cell proliferation partially through KLF5."

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"ATXN3L promotes breast cancer cell proliferation partially through KLF5."