IndraLab

Statements

USP8 inhibits proteolysis. 4 / 4
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"Further studies indicated that AUF1 protein degradation was mediated by upregulating USP8 transcription, which was modulated by its negative regulatory transcription factor Sp1."
30604907
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"This study shows that inhibition of USP8 specifically causes FGFR2 proteolysis through the proteasome system in ARID1A-deficient cells."
40074856
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"To evaluate whether proteolysis of these proteins is induced by suppression of USP8, we examined changes in the expression of these proteins in ARID1A-proficient and ARID1A-deficient cells treated with a USP8 inhibitor (Fig. 4C, Supplementary Fig. 4A)."
40074856
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"The aberrant hormone secretion in corticotroph adenomas is regulated by HSP90 and other chaperones that control protein folding in response to cellular stress on the one hand and USP8 triggering protein degradation by the proteasome on the other hand."
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