IndraLab

Statements

UCHL1 activates cell cycle. 8 / 8
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"Contradictorily, UCHL1 has recently been shown to induce G0/G1 cell cycle arrest and apoptosis by stabilizing p53 and has also been shown to be frequently silenced in primary breast tumors, but not in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression."
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"UCHL1 promoted cell cycle progression and DNA repair through regulating TS."
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"Suppression of UCHL1 protein level by LDN-5744 inhibitor could arrest the cell cycle in G1 phase in cell lines."
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"UCH-L1 has been shown to modulate the levels of several cell cycle regulators in cancer cells including cyclin D [XREF_BIBR] and p53 [XREF_BIBR]."
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"The related mechanisms for this resistance appear to involve UCHL1 promoting cell cycle progression and DNA repair."
32483437
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"The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer."
22279545
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"UCHL1 has been observed to be epigenetically regulated in other cancers, and is believed to induce G0/G1 cell cycle arrest and apoptosis by stabilization of p53."
23894057