IndraLab

Statements

UCHL1 activates cell cycle. 10 / 10
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"UCHL1 promoted cell cycle progression and DNA repair through regulating TS."
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"The first insight is that the UCHL1 gene can promote cell cycle progression due to its overexpression in PCC, but more studies are needed to elucidate the distinct role of this gene in PCC.RGS5 (Regulator of G Protein Signaling 5), a regulator of G-protein signaling, is overexpressed in various cancers [[122], [123], [124]], including PCC [111]."
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"UCHL1 gene silencing limits the proliferation of endometrial cancer cells and delays the cell cycle [35]."
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"Contradictorily, UCHL1 has recently been shown to induce G0/G1 cell cycle arrest and apoptosis by stabilizing p53 and has also been shown to be frequently silenced in primary breast tumors, but not in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Suppression of UCHL1 protein level by LDN-5744 inhibitor could arrest the cell cycle in G1 phase in cell lines."
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"The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer."
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"Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression."
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"The related mechanisms for this resistance appear to involve UCHL1 promoting cell cycle progression and DNA repair."
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"UCH-L1 has been shown to modulate the levels of several cell cycle regulators in cancer cells including cyclin D [XREF_BIBR] and p53 [XREF_BIBR]."
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"UCHL1 has been observed to be epigenetically regulated in other cancers, and is believed to induce G0/G1 cell cycle arrest and apoptosis by stabilization of p53."
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