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JAK-STAT activates USP18. 2 / 2
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"In the initial experiments demonstrating IFN desensitization, ISGF3 gel shift assays and STAT1 phosphorylation levels indicated that the presence of IFN-beta failed to result in prolonged JAK-STAT signaling in USP18 expressing cells; in contrast, signaling was maintained in Usp18 -/- cells."
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"USP18 is induced by JAK-STAT signaling, and the resulting protein product then competes with JAK1 for binding to the intracellular domain of IFNAR2 [XREF_BIBR]."
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