IndraLab

Statements

3',5'-cyclic AMP inhibits KCNK2. 10 / 10
| 10
reach
"In this regard, of the 15 members of the K2P K + channels family, only TREK-1 and TREK-2 are inhibited by cAMP."
23858003
reach
"Because cAMP analogs inhibited increase of the PDBu elicited K2P currents produced by divalent cataions, we suggest that cAMP may inhibit TREK1 channel without PKA activation."
24086441
reach
"TREK channels are also inhibited by an increase in cAMP, which is counteracted in case of Gi signaling [XREF_BIBR]."
33396826
reach
"Accordingly, it was previously reported that TREK-1 inhibition by cAMP is voltage dependent and less effective at positive potentials."
23858003
reach
"Previously, it had been shown that TREK-1 inhibition by cAMP was voltage dependent and less effective at positive potentials."
23858003
reach
"This hypothesis is supported by an earlier report that suggested that cAMP might inhibit the TREK1 channel independently from PKA in bovine adrenal zona fasciculata cells XREF_BIBR."
24086441
reach
"The decrease in cAMP concentration (as a result of reduced adenylate cyclase activity) in 5-HT neurons is also thought to induce TREK-1 opening because of a consequent reduction of phosphorylation of Ser333 by PKA XREF_BIBR."
20405001
reach
"TREK-1 and TREK-2 (which was not represented on the original Affymetrix chip) are inhibited by cAMP via PKA and exhibit outward rectification in physiological solutions [XREF_BIBR]."
17643200
reach
"Conversely, TREK-1 channels are inhibited by cAMP and following Gαq and Gαs activation [16,22,26]."
31511966
reach
"Adrenocorticotropic hormone and cAMP may inhibit TREK-1 by a PKA independent signaling pathway XREF_BIBR."
24086441