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3',5'-cyclic AMP inhibits KCNK2. 17 / 17
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"Previously, it had been shown that TREK-1 inhibition by cAMP was voltage dependent and less effective at positive potentials."
23858003
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"The decrease in cAMP concentration (as a result of reduced adenylate cyclase activity) in 5-HT neurons is also thought to induce TREK-1 opening because of a consequent reduction of phosphorylation of Ser333 by PKA XREF_BIBR."
20405001
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"Conversely, TREK-1 channels are inhibited by cAMP and following Gαq and Gαs activation [16,22,26]."
31511966
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"Activation of the cAMP – dependent PKA inhibits the activity of TREK1 as has been demonstrated by direct application of non-hydrolysable cAMP or by pharmacological activation of PKA [ 9 , 15 , 46 , 54[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29883692
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"Adrenocorticotropic hormone and cAMP may inhibit TREK-1 by a PKA independent signaling pathway XREF_BIBR."
24086441
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"This hypothesis is supported by an earlier report that suggested that cAMP might inhibit the TREK1 channel independently from PKA in bovine adrenal zona fasciculata cells XREF_BIBR."
24086441
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"This activation was reported to be transient followed by an inhibition, process attributable to an increase in the intracellular cAMP concentration by riluzole that produces a PKA-dependant inhibition[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24561669
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"Accordingly, it was previously reported that TREK-1 inhibition by cAMP is voltage dependent and less effective at positive potentials."
23858003
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"The AA-activated K + current in corticotropes was reduced by fluoxetine, chlorpromazine, extracellular acidification, diphenylbutylpiperidine antipsychotics and the membrane permeable cAMP analog (8CP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22225940
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"Because cAMP analogs inhibited increase of the PDBu elicited K2P currents produced by divalent cataions, we suggest that cAMP may inhibit TREK1 channel without PKA activation."
24086441
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"Accordingly, the permeant derivative of cAMP (CPT-cAMP) reversibly inhibits macroscopic TREK1 currents expressed in COS cells and impedes the activation of the current by RIL (Duprat et al., 2000; Moha ou Maati et al., 2011)."
30964046
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"We have previously reported that cAMP binds with high affinity to the Popeye domain, abolishing the current modulation of TREK-1 channels [ 9 ]."
32535041
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"Application of the cell-permeable cAMP analog, 8-CPT-cAMP to mouse corticotropes attenuated the TREK-1 current at a wide-range of potentials [5] ."
22225940
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"TREK channels are also inhibited by an increase in cAMP, which is counteracted in case of Gi signaling [XREF_BIBR]."
33396826
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"In this regard, of the 15 members of the K2P K + channels family, only TREK-1 and TREK-2 are inhibited by cAMP."
23858003
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"As previously reported, increased cAMP by theophylline blocks any enhancement of TREK‐1 currents by POPDC1 (Fig 8D and E)."
36254885
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"TREK-1 and TREK-2 (which was not represented on the original Affymetrix chip) are inhibited by cAMP via PKA and exhibit outward rectification in physiological solutions [XREF_BIBR]."
17643200