IndraLab

Statements

Berberine inhibits COPS5. 3 / 3
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"24 Previous studies have shown that berberine can suppress the deubiquitinating enzyme CSN5, reduce the expression of PD‐L1 on the surface of tumor cells, activate CD8 T cells in the tumor microenvironment, and exert a tumor‐clearing effect."
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"Some strategies such as inhibition of cyclin-dependent kinase 4/6 (CDK4/6) by palbociclib and inhibition of CSN5 by curcumin or berberine were designed to enhance antitumor immunity [ xref ]."
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"Berberine derived from Coptis chinensis has been shown to degrade PD-L1 by inhibiting the activity of CSN5 in NSCLC 99."
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