IndraLab

Statements

USP28 inhibits HIF1A. 4 / 4
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"GSK-3beta regulates cell growth, migration, and angiogenesis via Fbw7 and USP28 dependent degradation of HIF-1alpha."
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"In conclusion, knockdown of USP28 enhanced the radiosensitivity of EC cells by destabilizing c-Myc and enhancing the accumulation of HIF-1alpha."
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"In their following study, they found that GSK3beta regulated cell growth, migration and angiogenesis via Fbw7 and USP28 dependent degradation of HIF1alpha [9]."
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"A study has proposed a novel mechanism by which USP28 upregulates angiogenesis by antagonizing GSK-3beta (glycogen synthase kinase-3beta) and FBW7 dependent degradation of HIF-1alpha (hypoxia inducible factor-1alpha), a major regulator of angiogenesis, carcinogenesis, and various processes by which cells adapt to hypoxic conditions."
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