IndraLab

Statements

OTUB1 activates RNF168. 2 / 2
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"This suggests that the formation of DNA damage induced poly-ubiquitin chains is continually suppressed by OTUB1, possibly to prevent hyper-activation of the RNF8 and RNF168 response [35 **]."
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"revealed that OTUB1 negatively regulates the DDR by inhibiting the RNF168 pathway and showed that depletion of the negative DDR regulator is able to partially rescue the suppressed IR induced 53BP1 focus formation caused by ATM inhibitor."
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