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USP9X activates doxorubicin. 4 / 4
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"In addition, we explored the underlying mechanisms of the combined therapy, and showed that usp9x inhibition by WP1130 promoted the degradation of p53 in doxorubicin-treated HCC cells.Human liver canc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"WP1130 also increases sensitivity to doxorubicin via degrading p53 by a USP9X dependent mechanism in HCC cells XREF_BIBR."
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"Our previous study found that, as a potential downstream gene of miR-212, USP9X promote doxorubicin resistance in HCC [ 24 ]."
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"Results showed that downregulation of usp9x enhanced the doxorubicin cytotoxicity in Huh7, HepG2, and SNU387 cells except for Hep3B cells ( Fig. 4E–H )."
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