IndraLab

Statements

USP13 inhibits PIK3C3. 2 / 2
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reach
"Since USP13 could regulate several substrates in other cancers including MCL1, SKP2, MITF, PTEN, TOPBP1, and c-MYC as described above, ZHX2 could be one of downstream targets for USP13 and other substrates could contribute to the lack of complete rescue in ccRCC, which remains to be further explored.Spautin-1 was previously found to be the inhibitor for both USP10 and USP13 by promoting the degradation of Vps34 (39)."
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reach
"USP10 and USP13, two ubiquitin‐specific peptidases, can target the Beclin1 subunit of Vps34‐Beclin1 and promote the degradation of the Vps34 complex."
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