IndraLab

Statements

PE inhibits KCNK2. 5 / 5
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reach
"Interestingly, we found that PE 12-27 was able to strongly inhibit TREK-1 activity (28.4 +/- 9.9%, n = 22, p = 0.03; Figures XREF_FIG)."
28955242
reach
"Only, the PE 22-28 was able to efficiently block TREK-1 activity (55.46 +/- 4.6%, n = 13, p < 0.0001)."
28955242
sparser
"Consequently, the inhibition of TREK-1 by PE and its shorter designed analog spadin induce a potent antidepressant effect in numerous depressive-like behavior tests These results confirmed that targeting TREK-1 channels by a peptide designed from the endogenous PE could represent a new concept in the antidepressant drug design."
30670975
eidos
"Consequently , the inhibition of TREK-1 by PE and its shorter designed analog spadin induce a potent antidepressant effect in numerous depressive-like behavior tests These results confirmed that targeting TREK-1 channels by a peptide designed from the endogenous PE could represent a new concept in the antidepressant drug design ."
30670975
reach
"With PE 22–28, two other analogs were retained for further studies, as they inhibit the TREK-1 channel with a higher potency."
30291907