IndraLab

Statements

USP12 activates autophagy. 17 / 17
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"Usp12 induction of autophagy is a potential mechanism by which Usp12 confers neuroprotection in HD models."
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"Publisher Correction : Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington 's disease."
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"Depletion of USP12 suppressed cell growth and clonogenicity and inhibited autophagy ."
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"Deubiquitylase USP12 induces pro-survival autophagy and bortezomib resistance in multiple myeloma by stabilizing HMGB1."
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"Another possibility is that Usp12 stimulation of autophagy confers neuroprotection primarily by clearing cargo other than mHTT."
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"Usp12 stimulation of autophagy, in the context of mHTT, could lead to more efficient cargo loading in autophagosomes, and thereby reduce mHTT associated toxicity."
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"Both alpha-synuclein and TDP-43 are substrates for autophagic degradation XREF_BIBR, XREF_BIBR, XREF_BIBR, and so, we might predict that stimulation of autophagy by Usp12 overexpression would also be neuroprotective in the related PD and ALS neuron models."
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"USP12 also non-catalytically induces cell autophagy in Huntington’s disease ."
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"Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington 's disease."
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"Depletion of USP12 suppressed cell growth and clonogenicity and inhibited autophagy."
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"Surprisingly, the catalytic activity of Usp12 is not required to protect against neurodegeneration or induce autophagy."
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"Also , USP12 causes autophagy and confer neuroprotection in Huntington 's disease ( HD ) [ 184 ] ."
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"Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease."
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"Other enzymes are known to improve autophagy, as was shown for the deubiquitinating enzyme USP12 that induces neuronal autophagy."
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"USP12 increased autophagy via ATG7-dependent way by potentiating LC3B turnover (measured by optical pulse labeling assay) and increased the number of autophagic structures identified by EM."
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"Furthermore, USP12 induces MM cell autophagy via deubiquitinating and stabilizing HMGB1."
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"Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease."
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