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USP46 deubiquitinates DTL. 2 / 2

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"Then, USP46 deubiquitinates Cdt2 leading to continuous regulation of the CRL4 Cdt2 substrates and cell cycle deregulation [ 10 ] ( Figure 3 A)."

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"It has been shown earlier in HR HPV cancer cells that E6 protein protects Cdt2 from ubiquitin-mediated degradation by recruiting a deubiquitinase, USP46 to deubiquitinate and stabilise Cdt2, which is essential for proliferation and survival of these cells [14]."

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USP46 deubiquitinates DTL. 2 / 2

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