IndraLab

Statements

FlaG binds YOD1. 4 / 4
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"It was found that the level of CDK1 ubiquitination was significantly decreased compared with YOD1-T-OTUD and YOD1-T-ZnF mutant, but increased in the full-length FLAG-YOD1 and YOD1-T-UBXL mutant (Fig.  xref G)."
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"Next, we expressed full-length FLAG-YOD1 and different truncation mutants in HEK293 cells and co-immunoprecipitations using the anti-FLAG antibodies or anti-CDK1 antibodies confirmed that CDK1 bound to the Znf domain of YOD1, but not to the N-terminal UBX region and central otubain region of YOD1 (Fig.  xref C)."
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"As WT YOD1 overexpression also significantly reduced the amount of K48-Ub inside blebs ( xref A,B), we expressed WT YOD1-FLAG in WT and TorsinKO cells undergoing heat shock stress ( xref H)."
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"However, when WT YOD1-FLAG was expressed, this heat shock-specific increase in K48-Ub was significantly reduced ( xref H)."
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