IndraLab

Statements

BAP1 decreases the amount of HIF1. 2 / 2
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"We found the opposite to be true: BAP1 primary cells had reduced HIF-1α levels in hypoxia, and mesothelioma cells carrying biallelic BAP1 mutations almost constantly lost nuclear HIF-1α."
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"Mutations in BAP1 that disrupt its function result in decreased levels of HIF-1α, implicating BAP1 as a key regulator of HIF-1α stability in response to low oxygen levels ."
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