IndraLab

Statements

Lumefantrine inhibits KCNH2. 4 / 4
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"The estimated IC 25 -value for lumefantrine block of the hERG tail current was 1.2 mug/ml (2.27 muM)."
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"In conclusion, lumefantrine and desbutyl-lumefantrine inhibited significantly the hERG tail current with a higher IC50-value than mefloquine, chloroquine and halofantrine."
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"We showed that lumefantrine and desbutyl-lumefantrine inhibited the hERG tail current with similar IC 50 -values."
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"Lumefantrine inhibited the hERG tail current in a concentration dependent manner, with a significant inhibition of the tail current observed at concentrations of 3 mug/ml and above."
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