IndraLab

Statements

Lumefantrine inhibits KCNH2. 5 / 5
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"Lumefantrine inhibited the hERG tail current in a concentration dependent manner, with a significant inhibition of the tail current observed at concentrations of 3 mug/ml and above."
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"The estimated IC 25 -value for lumefantrine block of the hERG tail current was 1.2 mug/ml (2.27 muM)."
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"Lumefantrine and desbutyl-lumefantrine inhibited wild-type hERG channel activity in stably transfected HEK293 cells with an IC50 of 8.1 and 2.6 microM, respectively [69]."
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"We showed that lumefantrine and desbutyl-lumefantrine inhibited the hERG tail current with similar IC 50 -values."
14729380
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"Further experiments in HEK‐293 cells stably expressing hERG channels showed that halofantrine, chloroquine, mefloquine, lumefantrine, piperaquine phosphate and dihydroartemisinin blocked the hERG current in a concentration‐dependent manner (Borsini et al., 2012)."
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