IndraLab
Statements
OTUD5 inhibits histone exchange. 1 / 1
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1
reach
"Thus, our work propose that FACT is an important factor in this in cis regulation, and that FACT is subject to regulation by OTUD5–UBR5 complex for the non-lesion stalling of Pol II.Our work leaves several open-ended questions; our data collectively suggest that OTUD5 and UBR5 repress FACT histone exchange activity, but how does this complex exactly achieve this?"