IndraLab

Statements


RNF41 ubiquitinates USP8. 3 / 3
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reach
"Mechanistically, the E3 ligase Nrdp1 indirectly destabilizes the ESCRT-0 complex by ubiquitinating and suppressing USP8."

sparser
"We further demonstrated that this results from RNF41-dependent ubiquitination and suppression of the deubiquitinating enzyme USP8, which abrogates ESCRT-0 functionality and accounts for the rerouting of cytokine receptors ( xref )."

trips
"RNF41 redistributes and ubiquitylates USP8, and reduces USP8 levels."