IndraLab

Statements

COPS4 activates COPS5. 2 / 2
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reach
"Interaction of the complex with a NEDDylated CRL leads to a series of conformational change events in Csn2, Csn4 and Csn7, triggering rearrangements in the Csn5 and Csn6 dimer, resulting in Csn5 activation by priming the Csn5 JAMM and MPN + motif for deNEDDylation [XREF_BIBR, XREF_BIBR]."
33099217
reach
"In the presence of CRL4A, conformational changes in CSN2, CSN4, and CSN7 affect the CSN5-CSN6 dimer and activate CSN5."
39600336