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OTUD5 activates HNF4A. 4 / 4
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"However, the inhibition of ERK1/2 but not JNK and p38 MAPK pathways enhanced OTUD5-mediated promotion of HNF4α (Fig. 7D)."
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"The data of PCR showed that knockdown of OTUD5 significantly downregulated the mRNA of HNF1ɑ and HNF4ɑ (Fig. 6B,C)."
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"Conversely, the overexpression of OTUD5 could upregulate the mRNA of HNF1ɑ and HNF4ɑ (Fig. 6E–F)."
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"Meanwhile, overexpression of OTUD5 could inhibit the MAPK pathway and then increase the expression of HNF4a, and ERK1/2 signaling was required for OTUD5-mediated activation of HNF4alpha, promoting HBV replication."
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