IndraLab

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OLR1 activates TRPA1. 4 / 4
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"In this study, we found that oxLDL activated macrophage TRPA1 channels; however, we cannot verify the potential contribution of the oxidative products to oxLDL-induced activation of TRPA1 channels observed in this study."
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"OxLDL activates TRPA1 channels in macrophages."
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"To further study whether oxLDL could directly activate TRPA1, we used a gain-of-function strategy to measure Ca 2+ permeability of TRPA1 channels by re-expressing full-length TRPA1 in HEK293 cells, which lack TRP channels."
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"Blocking TRPA1 activation by HC030031 abrogated oxLDL- or AITC-induced Ca 2+ influx in TRPA1-re-expressed HEK293 cells (Fig. xref C-D)."
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