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Modified KCNH2 leads to the sumoylation of NBN. 1 / 1

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"Primarily, it was found that : (1) exposure of cells to ATO and Ang II significantly reduced the expression of HERG protein; (2) both ATO and Ang II stimulation increased PML SUMOylation and NBs aggregation, promoting recruitment with Pin1; (3) translocation of Pin1 into PML-NBs led to upregulation of TGF-beta1, eventually inhibiting HERG expression through PKA activation."

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Modified KCNH2 leads to the sumoylation of NBN. 1 / 1

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