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UCHL5 activates cell population proliferation. 23 / 23
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"The CCK-8 assays showed that UCHL5 ablation significantly suppressed the proliferation rates of PAAD cells ( Fig. 3 D), whereas UCHL5 overexpression enhanced PAAD cells proliferation ( Fig. 3 E)."
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"Lastly, we also found that UCHL5 knockout could notably inhibit cell proliferation abilities of PAAD cells, whereas ectopic expression of UCHL5 could rescue the impaired cell growth abilities ( Fig. 3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Proteasomal deubiquitinase UCH37 inhibits degradation of beta-catenin and promotes cell proliferation and motility."
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"Functional assays also showed that UCHL5 overexpression could notably enhance cell proliferation, and self-renewal capacities."
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"UCHL5 knockdown in LUAD cells significantly inhibited cell proliferation and reduced the expression of key cell cycle proteins."
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"UCHL5 knockdown inhibits LUAD cell proliferation via regulation of cell cycle proteins."
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"UCHL5 knockdown by two siRNA segments significantly inhibited cell proliferation in Hela cells."
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"However, another study suggested that UCHL5 stabilizing NFRKB, a chromatin-remodeling protein, may promote GC cell proliferation and metastasis [87]."
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"UCHL5 knockdown markedly inhibited cell proliferation via regulating cell cycle proteins."
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"UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling."
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"40 In previous understanding, DNMT1 and DNMT3a promote thyroid cancer development by promoting hypermethylation and transcriptional activation of ICAM5;41 and the overexpression of UCHL5 enhances bladder cancer cell proliferation and migration through the AKT/mTOR pathway via c-Myc, SLC25A19, and ICAM5 transformation."
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"65 b-AP15, an inhibitor of USP14 and UCH-L5, obviously suppresses the proliferation of cancer cells ( Table 2 )."
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"Overexpression of UCHL5 enhances, while silencing of UCHL5 represses, cancer cell proliferation and migration by c-Myc, SLC25A19, and ICAM5 transformation via AKT/mTOR pathways."
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"UCHL5 promotes the proliferation and metastasis of HCC cells in vivo."
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"Deletion of UCH37 also down-regulated the transcription of c-Myc, a downstream effector of beta-catenin, and inhibited cell proliferation and motility."
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"We also found that UCHL5 downregulation significantly suppressed both tumor growth in vivo and cell proliferation and migration in vitro ."
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"UCH37 interacts with COPS5 to induce the ubiquitination and degradation of p53 and p21 , promoting cell proliferation ."
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"We verified that UCHL5 activates the AKT/mTOR pathway to enhance migration and proliferation."
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"UCHL5 combined with DRAIC can increase the proliferation and metastasis of GC cells via ubiquitination [28]."
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"UCHL5 knockdown markedly inhibited cell proliferation via regulating cell cycle proteins ."
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"In another study on bladder cancer, UCHL5 was shown to promote tumor cell proliferation and migration by activating c-Myc through the AKT/mTOR signaling pathway [40]."
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"Further research showed that silencing UCHL5 in LUAD cells significantly inhibited cell proliferation and reduced the expression of key cell cycle proteins [43]."
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"Subsequent in vitro studies revealed that UCHL5 knockout significantly inhibited cervical cancer cell proliferation and migration."
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