IndraLab

Statements

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"Mechanistically, uPAR forms functional complexes with vitronectin-binding integrin αvβ3 on osteoclasts and tumor cells, coordinating with Src-family kinases to activate downstream signaling (e.g., c-Src, Pyk2, p130Cas) that enhances osteoclast differentiation, extracellular matrix degradation, and tumor cell colonization in bone metastasis models [ xref ]."
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"Reported association of uPAR with αvβ3 in cell membrane lipid rafts can foster activation of metalloproteinases that efficiently degrade collagen xref , xref and may thereby contribute to αvβ3 mediated collagen adhesion."
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"Modification of the uPAR–αvβ3 integrin interaction in podocyte has been proposed as the cause of proteinuria in experimental and human focal segmental glomerulosclerosis (FSGS), a condition characteri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In mouse podocytes, the uPAR–αvβ3 integrin signaling can activate the Rho family GTPase Cdc42 in a vitronectin-dependent manner."
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