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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

APP decreases the amount of KCNQ2. 2 / 2

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"In the hippocampus, the expression of the KCNQ 2 is probably reduced by the Abeta induced damage."

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"In this sense, it has been reported that in the septohippocampal system Abeta reduces not only KCNQ2 subunit expression and then, KCNQ conductance, altering the neuronal excitability but also the expression of the oxidative stress related genes superoxide dismutase 1 (SOD1), 8-oxoguanine DNA glycosylase (OGG1), and monamine oxidase A (MAOA)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...