IndraLab

Statements

ISO activates HCN4. 3 / 3
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"In the presence of PP2, ISO (0.1 muM) was unable to induce a positive shift of HCN4 activation (C) in contrast to ISO stimulation of HCN4 (XREF_SUPPLEMENTARY)."
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"To confirm this conclusion, we needed to provide direct evidence for a well established ISO stimulation of HCN4 that is inhibited by PP2."
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"PP2 inhibited HCN4 and prevented the enhancement of HCN4 by ISO."
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