IndraLab

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USP20 activates reticulophagy. 4 / 4
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"The results demonstrated that in USP20 knockdown cells, the expression of wild-type USP20 or RETREG1 fully restored reticulophagy function, whereas expression of the catalytically inactive mutant USP20 or the FFAT1/2-deleted mutant USP20[ΔFFAT1/2] failed to initiate reticulophagy (Figure 7A-B)."
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"These observations strongly support the notion that USP20 positively regulates reticulophagy."
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"Additionally, USP20’s interaction with VAPs further enhances its role in promoting efficient reticulophagy."
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"USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy."
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