IndraLab
Statements
Lovastatin inhibits JUN. 2 / 3
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2
reach
"In one study, simvastatin, atorvastatin, and lovastatin were shown to downregulate nuclear factor-kappa B (NF-kappaB), activator protein-1, and hypoxia-inducible factor-1alpha in endothelial and arterial smooth muscle cells, which play a role in downstream activity of pro-inflammatory cytokines, chemokines, adhesion molecules, and growth factors (Dichtl et al. 2003)."
reach
"Interestingly, lovastatin appears to down-regulate nuclear factor kappa B (NF-κB) and activator protein-1 (AP-1) in a dose-dependent manner, with concomitant suppression of key chemokines, including those regulated upon activation normal T-cell expressed and secreted (RANTES) and the MCP-1, resulting in the reduced production of IL-2, IL-4, and IFN-γ, and ultimately decreasing the inflammatory cell infiltration of arterial walls."