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"These assays will allow for examining effects of SCN2A mutations on likely PTM events such as evaluating SUMOylation, calcium-calmodulin and FGF14 binding to the mutated Nav1.2."

"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."