IndraLab

Statements

STUB1 binds TP53 and MDM2. 4 / 4
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sparser
"We then investigated whether BAG5 inhibits MDM2 and CHIP-mediated mutp53 degradation through inhibiting the mutp53–MDM2 and mutp53–CHIP interaction."
27807478
sparser
"Notably, co-expression of BAG5 clearly decreased the mutp53–MDM2 and mutp53–CHIP interaction in a dose-dependent manner ( xref )."
27807478
sparser
"Unlike wild type p53, the unfolded and aggregated mutant p53 proteins are bound by HSP90, which blocks the interaction of endogenous MDM2 and CHIP (carboxy-terminus of Hsp70-interacting protein) with mutant p53."
30956950
sparser
"The mutp53–MDM2 and mutp53–CHIP interaction was examined in H1299 cells transfected by expression vectors of mutp53 (R175H), MDM2, CHIP along with different amount of BAG5 by co-IP assays."
27807478