A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

STUB1 binds TP53 and MDM2. 4 / 4
| 4
sparser
"Notably, co-expression of BAG5 clearly decreased the mutp53MDM2 and mutp53CHIP interaction in a dose-dependent manner ( xref )."
sparser
"Unlike wild type p53, the unfolded and aggregated mutant p53 proteins are bound by HSP90, which blocks the interaction of endogenous MDM2 and CHIP (carboxy-terminus of Hsp70-interacting protein) with mutant p53."
sparser
"The mutp53MDM2 and mutp53CHIP interaction was examined in H1299 cells transfected by expression vectors of mutp53 (R175H), MDM2, CHIP along with different amount of BAG5 by co-IP assays."
sparser
"We then investigated whether BAG5 inhibits MDM2 and CHIP-mediated mutp53 degradation through inhibiting the mutp53MDM2 and mutp53CHIP interaction."