IndraLab

Statements

USP4 activates TP53. 7 / 7
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"Another example is that USP4 expression increases p53 transcriptional activity by stabilizing ARF-BP1, which is an E3 ubiquitin ligase of p53 [ 24 ]."
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"In addition to these newly identified nuclear functions, both USP4 and USP15 are well known to function in the cytosol, i.e. USP4 modulates the Wnt and beta-catenin, NF-kappaB, p53 and TGF-beta signaling pathways while USP15 performs functions in the TGF-beta receptor and NF-kappaB signaling pathways."
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"However, in response to cisplatin treatment, USP4 deficiency significantly augmented melanoma cells apoptosis by activating p53 signalling."
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"However, in response to cisplatin induced stress, the knockdown of USP4 could markedly increase the apoptotic rate of melanoma cells, and USP4 deficiency sensitized melanoma cell to cisplatin induced apoptosis by activating p53 pathway."
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"Similarly, knockdown of USP4 significantly decreases cell viability in a p53 dependent manner after treating GMB cells with temozolomide."
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"In contrast, silencing USP4 by shRNA remarkably increased the p53 activity in response to DNA damage or not (XREF_FIG)."
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"USP4 regulates the cell cycle and apoptosis and promotes tumor cell proliferation by regulating the p53 and downstream protein expression."
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