IndraLab

Statements

S4 activates KCNH2. 2 / 2
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"There are two obvious possibilities : (1) either the slow fluorescence reflects S4 movements that underlie HERG activation gating, or (2) the probe is able to sense conformational changes occurring in or near the pore and, thus, simply reports the opening and closing of the pore."
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"Thus, these electrical measurements supported the conclusion from the fluorescence measurements that slow S4 movement underlies hERG gating kinetics."
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