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Risperidone inhibits KCNH2. 4 / 11
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"This analysis shows that enhancements of endogenous HF oscillations in HR were also found in beagle dogs with dofetilide and with other hERG blockers such as cisapride, haloperidol, risperidone, DL sotalol, terfenadine and thioridazine."
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"In addition, risperidone inhibits hERG channels in human cardiac myocytes with an IC 50 value of 0.148 μM."
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"Risperidone and paliperidone inhibited the hERG tail currents in a concentration dependent manner with IC 50 values of 0.16 and 0.57 muM, respectively."
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"For example, risperidone inhibits cardiac human ether-a-go-go gene (hERG) channels, which may explain its prolongation of the QT interval ( Crumb et al., 2006 )."
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