IndraLab

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6 1 | 2

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"This analysis shows that enhancements of endogenous HF oscillations in HR were also found in beagle dogs with dofetilide and with other hERG blockers such as cisapride, haloperidol, risperidone, DL sotalol, terfenadine and thioridazine."

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"Risperidone and paliperidone inhibited the hERG tail currents in a concentration dependent manner with IC 50 values of 0.16 and 0.57 muM, respectively."