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(E)-4-hydroxynon-2-enal inhibits CTSB. 2 / 2

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"Both HNE and MDA inhibited the cysteine proteases cathepsin B and L at a concentration of 1 microM by 88%-94% and this effect was due to HNE and MDA adducts in the active center of these proteases [XREF_BIBR]."

26437435

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"HNE may also directly inhibit cathepsin B and other lysosomal cysteine proteases by covalently modifying the enzyme active site."

28095639

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IndraLab

Statements

(E)-4-hydroxynon-2-enal inhibits CTSB. 2 / 2

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