IndraLab

Statements

CTNNB1 phosphorylates CTNNB1 on T41. 5 / 5
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"Previous studies have verified that the beta-catenin destruction complex mediates sequential phosphorylation of beta-catenin at S45, T41, S37 and S33 for subsequent ubiquitination and proteasomal degradation and thereby maintains low baseline cytosolic levels of the protein in cancer cells XREF_BIBR, XREF_BIBR."
29789528
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"We speculate that the prominent nuclear accumulation of beta-catenin phosphorylated at T41 and S45 (XREF_FIG), together with evidence that it is largely a cadherin-free form of beta-catenin (XREF_FIG), raises the possibility that phospho-S45 may be a dedicated signaling form of beta-catenin."
20419129
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"Levels of stabilized form of β-catenin were visualized using the ABC antibody ( Fig. 1 C) that recognize β-catenin that is not phosphorylated at residues S37 and T41, two of the sites that are phospho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18598779
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"In the absence of Wnt signaling, the beta-catenin destruction complex continuously phosphorylates beta-catenin protein at Ser 33, 37, 45 and Thr 41 to target beta-catenin for degradation via an ubiquitin dependent pathway XREF_BIBR, XREF_BIBR, XREF_BIBR."
25003522
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"This phosphorylation renders beta-catenin a primed substrate for glycogen-synthase kinase 3 (GSK3), which, in turn, continue to phosphorylate beta-catenin at T41, S37, and S33."
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