IndraLab

Statements

HCN1 binds APP. 11 / 11
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"Therefore, HCN1 may form a complex with APP and X11 or X11L to regulate the generation of Aβ (Saito et al., 2012)."
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"To show whether HCN1 directly binds to APP without mediation by X11 and X11L, FLAG-APP and HCN1 were transiently expressed in N2a cells and a co-immunoprecipitation assay was performed."
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"Hence, HCN1 apparently interacts with the extracellular domain of APP (Figure  xref ) and with both X11 and X11L in the cytoplasm (Figure  xref H–K, Figure  xref B)."
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"The association between APP and HCN1 was next confirmed in the EC."
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"To show whether HCN1 directly binds to APP without mediation by X11/X11L, FLAG-APP and HCN1 were transiently expressed in N2a cells and a co-immunoprecipitation assay was performed."
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"Taken together, the results shown in Figure  xref indicate that HCN1 associates with APP through its extracellular (luminal) domain."
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"Association of HCN1 with APP in vivo and in vitro ."
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"A previous study reported that HCN1 can form a complex with APP in the murine brain and levels of this protein are significantly reduced in the brains of sporadic AD patients compared with age-matched healthy subjects [ xref ]."
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"Furthermore, administration of ZD7288 did not influence the interaction of HCN1 with APP (Additional file xref : Figure S5)."
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"On the other hand, the present study showed that HCN1 physically associated with APP through the extracellular domain of APP."
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"On the other hand, the present study showed that HCN1 physically associated with APP through the extracellular domain of APP."
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