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USP8 activates DDX3X. 2 / 2

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"USP8 cleaved K27-linked polyubiquitin chains from the IDR of DDX3X and enhanced the condensation of DDX3X, which subsequently promoted cGAS activation."

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"In turn, enhanced DDX3X condensation by USP8 facilitates the phase separation of cGAS."

38795350

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USP8 activates DDX3X. 2 / 2

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