IndraLab

Statements

USP18 inhibits signaling. 7 / 7
| 7
sparser
"USP18 inhibits IFN-α/β signaling, and its decrease is consistent with the higher levels of ISG expression in the patient’s blood ( xref )."
30075154
sparser
"To determine the molecular mechanisms by which USP18 inhibits TLR induced NF-κB signaling, we transfected 293T cells with MyD88, TRAF2, TRAF6, TAK1-TAB1, IKKα, IKKβ, or p65 subunit together with increasing amounts of USP18 plus the NF-κB luciferase reporter."
26240016
sparser
"These findings highlight the importance of studying whether USP18 has additional functional domain(s) and whether USP18 can inhibit TNF-α signaling by itself or in combination with other protein(s)."
30266866
sparser
"USP18 inhibits NF-κB signaling at the level of the IKK complex."
26240016
sparser
"Given that Usp18 inhibits IFN-I signaling, it will be important to further understand why increases in Usp18 expression do not correlate with a corresponding decrease in IFN-I stimulated gene expression."
26783074
sparser
"We hypothesized that USP18 may also prevent the phosphorylation of JAK1 after IFN-γR signaling, similarly to how USP18 inhibits IFNAR2 signaling."
30266866
sparser
"Splenic CD169+ macrophages selectively express the ubiquitin-specific protease Usp18 which inhibits interferon αβ receptor (IFNAR) signaling ( xref )."
22444627