IndraLab

Statements

OTUB1 inhibits CD8. 5 / 5
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"In an adoptive T cell therapy model, Otub1 deletion also profoundly enhanced the tumor-rejection activity of CD8 effector T cells, which was consistent with the role of Otub1 in regulating the metabolism and effector molecule expression of activated CD8 T cells."
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"Furthermore, OTUB1 depletion increases CD8 T cell infiltration, elevates serum IFN-γ, and augments anti-tumor immune responses in mouse models (30)."
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"These results suggest that Otub1 maintains CD8 T cell homeostasis and negatively regulates CD8 T cell activation."
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"This intricate relationship is further exemplified in NSCLC, in which the circular RNA insulin-like growth factor 2 mRNA-binding protein 3 (circIGF2BP3) modulates OTUB1 levels, counteracts the ubiquitinated degradation of PD-L1, and suppresses CD8 T-cell function, ultimately facilitating immune evasion [77]."
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"Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells."
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