IndraLab

Statements

COPS5 activates autophagy. 3 / 3
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"Therefore, these results indicate that CSN5 controlled p53 may drive a pro survival autophagy in diverse cancer cells response to curcumin."
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"Here, we found that Csn5 deficiency attenuated pathogenicity and enhanced autophagy in Magnaporthe oryzae."
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"Of note, CSN5 initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p 53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53 R273H."
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