IndraLab

Statements

P38 phosphorylates SCN10A. 12 / 12
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"Nrf2 Phosphorylation by ERK, P38 MAPKs, and PKCδ in PN3."
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"IL-1β sensitizes nociceptor neurons via p38 MAPK phosphorylation of Nav1.8 sodium channels, leading to increased action potential generation and resulting in mechanical and thermal hyperalgesia [28]."
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"P38 MAPK phosphorylation of Nav1.8 sodium channels allows IL-1β to sensitize nociceptor neurons, facilitating increased action potential and resulting in thermal and mechanical hypersensitivity ( Ebbi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is known that Nav1.8 in DRG neurons can be phosphorylated by p38 MAPK, resulting in an increase in the current density in sensory neurons [ xref ]."
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"These cytokines induce nociceptive neuron sensitization via p38 MAPK phosphorylation of Nav1.8 sodium channels [6] (Figure 1)."
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"Moreover, nociceptor sensitivity is influenced by TNF/α because TNF/α is also active in the p38 MAPK phosphorylation of Nav1.8 and Nav1.9 sodium channels and, therefore, alters neuron excitability [129,130]."
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"CXCL10 combined with CXCR3 could activate the p38 and ERK signaling pathways in DRG neurons [ xref ], and p38 could directly phosphorylate Nav1.8 and increase the density of Nav1.8-type currents."
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"Additionally, Nav1.8 within DRG neurons is a substrate for p38 mitogen-activated protein kinase (MAPK), and phosphorylation of Nav1.8 by p38 increases current density in these sensory neurons23."
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"Another study showed that p38 phosphorylates Nav1.8, increasing the trafficking of this channel at the membrane of DRG neurons (Hudmon et al., 2008)."
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"IL‐1β and TNF‐α sensitize nociceptive neurons via p38 MAPK phosphorylation of Nav1.8, TRPV1, and transient receptor potential ankyrine‐1 (TRPA1) channels, which then induces hyperalgesia to mechanical and thermal stimuli. xref , xref Estrogen and an agonist of G‐protein coupled estrogen receptor (GPER) increase mast cell degranulation, tryptase and histamine release, and hypersensitivity in a rat stress model while ovariectomy decreases these activities. xref "
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"We report here, for the first time, that Na(v)1.8 and p38 are colocalized in DRG neurons, that Na(v)1.8 within DRG neurons is a substrate for p38, and that direct phosphorylation of the Na(v)1.8 channel by p38 regulates its function in these neurons."
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"P38 may enhance I by phosphorylating the NaV1.8 channel or an associated protein."
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