IndraLab

Statements

P38 phosphorylates SCN10A. 7 / 7
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rlimsp
"It was reported that Nav1.8 and pp38 are colocalized in DRG neurons and p38 directly phosphorylates Nav1.8 to cause an increase in Nav1.8 current density23."
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"Nrf2 Phosphorylation by ERK, P38 MAPKs, and PKCδ in PN3."
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"Additionally, Nav1.8 within DRG neurons is a substrate for p38 mitogen-activated protein kinase (MAPK), and phosphorylation of Nav1.8 by p38 increases current density in these sensory neurons23."
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"P38 may enhance I by phosphorylating the NaV1.8 channel or an associated protein."
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rlimsp
"Additionally, Nav1.8 within DRG neurons is a substrate for p38 mitogen-activated protein kinase (MAPK), and phosphorylation of Nav1.8 by p38 increases current density in these sensory neurons23."
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"These cytokines induce nociceptive neuron sensitization via p38 MAPK phosphorylation of Nav1.8 sodium channels [6] (Figure 1)."
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"IL-1β sensitizes nociceptor neurons via p38 MAPK phosphorylation of Nav1.8 sodium channels, leading to increased action potential generation and resulting in mechanical and thermal hyperalgesia [28]."
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