IndraLab

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USP15 activates NRF1. 3 / 3
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"These results uncover a new regulatory mechanism that USP15 activates Nrf1 against the β-TrCP inhibition to maintain proteostasis."
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"This study demonstrates a new molecular mechanism of Nrf1 activation by the deubiquitination enzyme USP15 ( Fig. 4 B)."
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"Here, we report that USP15 (Ubiquitin-Specific Protease 15) activates Nrf1 in the nucleus by stabilizing it through deubiquitination."
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