IndraLab

Statements

USP15 activates NRF1. 2 / 2
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"Fukagai et al. xref had shown that USP15 could stabilize and activate Nrf1 in the nucleus through deubiquitination, and knockdown of USP15 reduced the expression of NRF1-induced proteasome, to participate in maintaining protein homeostasis at the transcriptional level."
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"This study demonstrates a new molecular mechanism of Nrf1 activation by the deubiquitination enzyme USP15 ( Fig. 4 B)."
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