IndraLab

Statements

CYLD inhibits CXCL8. 8 / 8
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"Additionally, similar result was also observed in human cervical epithelial HeLa cells ( xref ), which further suggests the generalizability of inhibition of IL-8 by CYLD."
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"In fact, CYLD overexpression significantly inhibited hypoxia triggered induction of IL-6 and IL-8."
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"Moreover, CYLD also negatively regulated IL-8 induction by nontypeable Haemophilus influenzae (NTHi), another major OM bacterial pathogen, via MKP-1-mediated ERK inactivation (66)."
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"Taken together, the CYLD suppression of ERK dependent IL-8 via MKP-1 may bring novel insights into the tight regulation of inflammatory responses and also lead to innovative therapeutic strategies for controlling these responses by targeting key negative regulators of inflammation."
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"MKP-1 and CYLD can synergistically inhibit production of neutrophil chemoattractant IL-8 from airway epithelial cells."
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"To further elucidate the role of CYLD in IL-8 levels, we used the specific MEK inhibitor, PD98059, to examine the involvement of the ERK pathway in CYLD mediated suppression of IL-8."
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"As shown in XREF_FIG, IL-8 induction is markedly inhibited by CYLD WT."
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"Additionally, similar result was also observed in human cervical epithelial HeLa cells (XREF_SUPPLEMENTARY), which further suggests the generalizability of inhibition of IL-8 by CYLD."
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