IndraLab

Statements

UCHL1 inhibits proteolysis. 4 / 4
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"At a cellular level, parkin and UCH-L1 mediate protein degradation via the UPS."
12428722
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"These results suggest that the promotion of UCHL1 on decidualization and modulation of dNKs by DSCs is dependent on the activation of JAK2/STAT3 signaling.UCHL1 is a deubiquitinating enzyme, and as its name implies, the function of UCHL1 relies on its C-terminal hydrolase to remove ubiquitin from proteins and thus inhibit protein degradation via the proteasome [35]."
38769534
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"This is worthy of further exploration to screen target proteins that UCHL1 may affect E synthesis.Theoretically, a true proteolysis-associated substrate of UCHL1 would be degraded by UCHL1 interference through its elevated protein ubiquitination level and interact with UCHL1 (28)."
37797697
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"As Uch-l1 is thought to stimulate protein degradation by generating free monomeric ubiquitin, the gad mutation appears to affect protein turnover."
10471497