IndraLab

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PKA activates CACNA1C. 7 / 7
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"We reported PKA-dependent (H-89 and PKI inhibited), enhanced clustering and expression of CaV1.2 channels on the t-tubule membrane of adult mouse cardiomyocytes after stimulation with ISO (Figures 2A,B)."
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"The commonly accepted model is that PKA increases CaV1.2 current by phosphorylating CaV1.2 alpha1C - and / or beta2B-subunits ( Fig. 1a ) ."
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"The action of GPBAR1 included PKA dependent activation of L-type Ca 2+ currents, which have been closely linked to vesicular exocytosis in pancreatic beta-cells XREF_BIBR, and would likely be mimicked by other G alphas -coupled receptors."
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"Recently it was suggested that the A kinase anchoring protein Cypher/ZASP is also important for PKA modulation of the Cav1.2 channel [ 36 ]."
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"The key phosphorylation sites underlying PKA modulation of Cav1.2 were recently mapped to serine 1700 and threonine 1704, with serine 1700 being the most critical for receptor mediated current enhance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The presence of AKAPs is critical for the reconstituted PKA-modulation of Cav1.2 in tsA201 cells."
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"Phosphorylation of Cav1.2 on Ser1928 by PKA augments Cav1.2 activity and synaptic plasticity [122], [128]."
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