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Statements


PKA activates CACNA1C. 3 / 3
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reach
"The action of GPBAR1 included PKA dependent activation of L-type Ca 2+ currents, which have been closely linked to vesicular exocytosis in pancreatic beta-cells XREF_BIBR, and would likely be mimicked by other G alphas -coupled receptors."

eidos
"The commonly accepted model is that PKA increases CaV1.2 current by phosphorylating CaV1.2 alpha1C - and / or beta2B-subunits ( Fig. 1a ) ."

reach
"We reported PKA-dependent (H-89 and PKI inhibited), enhanced clustering and expression of CaV1.2 channels on the t-tubule membrane of adult mouse cardiomyocytes after stimulation with ISO (Figures 2A,B)."