IndraLab

Statements

Estradiol inhibits NFKB1. 3 / 3
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"Sex differences in these clinical studies have not been examined, but the preclinical finding that estradiol inhibits pro-inflammatory cytokine gene expression, nuclear factor kappa B (NFkB) activation, and pro-inflammatory cytokine production, suggests they may occur."
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"High levels of estradiol, HCG and progesterone during the pregnancy can inhibit secretion of such NFkB induced inflammatory cytokines as IL-1, -2, -3, -5, -8, interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) by Mphis and T cells, while enhance the secretion of the monocyte deactivating cytokine, IL-10 [XREF_BIBR - XREF_BIBR]."
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"Likewise, a comparison between male immune cells exposed to 17β-estradiol and their untreated but stimulated counterparts demonstrated that estradiol negatively regulates the NFKB1, IRAK2, IL1B, IL1A, IL12A, IKBKB, and BTK genes, but does not affect the IRAK1 gene (180)."
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