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Estradiol inhibits NFKB1. 3 / 3
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"Likewise, a comparison between male immune cells exposed to 17β-estradiol and their untreated but stimulated counterparts demonstrated that estradiol negatively regulates the NFKB1, IRAK2, IL1B, IL1A, IL12A, IKBKB, and BTK genes, but does not affect the IRAK1 gene (180)."
38835761
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"High levels of estradiol, HCG and progesterone during the pregnancy can inhibit secretion of such NFkB induced inflammatory cytokines as IL-1, -2, -3, -5, -8, interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) by Mphis and T cells, while enhance the secretion of the monocyte deactivating cytokine, IL-10 [XREF_BIBR - XREF_BIBR]."
19683334
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"Sex differences in these clinical studies have not been examined, but the preclinical finding that estradiol inhibits pro-inflammatory cytokine gene expression, nuclear factor kappa B (NFkB) activation, and pro-inflammatory cytokine production, suggests they may occur."
21631473