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"The caspase-1 (interleukin 1beta converting enzyme; ICE) titrant 3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino) propionylamino] -4 -oxo-5-(2-oxo-2H-chromen-7-yloxy) pentanoic acid (1 (Dang, L. C., et al. (1996) Biochemistry 35, 14910-14916)) inhibits caspase-1 activity rapidly, while release of the 7-hydroxycoumarin fluorophore is much slower."