IndraLab

Statements

Calcium(2+) inhibits NFKBIA. 5 / 5
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reach
"The purpose of the present study was to test the hypothesis that TNF-alpha-induced dysregulation of [Ca (2+)] (i) in insulin producing beta-cells causes proteolytic degradation of IkappaBalpha and consequently leads to the transcriptional activation of nuclear factor-kappaB (NF-kappaB)."
21494319
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"The Ca 2+ chelator BAPTA-AM markedly suppressed nuclear accumulation of IkappaBalpha and its degradation."
20797629
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"[Ca 2+] i increase is considered to mediate the degradation of IkappaB-alpha and the subsequent activation of NF-kappaB XREF_BIBR, XREF_BIBR."
23805318
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"We show here that IL-3 induces a SFK- and Ca 2+ -dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IkappaBalpha degradation and NFkappaB activation."
25749030
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"All tested IkappaBalpha targets (n = 12) were robustly induced by TNFalpha treatment (up to 12-fold) following different kinetics (XREF_FIG) and to a lesser extent (up to 3-fold) by Ca 2+ treatment (XREF_SUPPLEMENTARY) or IkappaBalpha KD (XREF_SUPPLEMENTARY)."
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