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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

TP53 bound to TP53BP2 activates TP53. 3 / 3

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"ASPP2 can bind to p53 and enhance the apoptotic capabilities of p53 by guiding it to the promoters of pro apoptotic genes."

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"The p53 binding protein 2 (p53BP2) that binds to both p53 and Bcl2, enhances the trans-activation function of p53 and may induce the cdk inhibitor p21."

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"3 ASPP2 binds to p53 through its C terminus to stimulate the transactivation function of p53 on the promoters of pro apoptotic genes, such as the genes encoding Bax, PIG3 and PUMA."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

TP53 bound to TP53BP2 activates TP53. 3 / 3

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